There is no established medical treatment for LHON, though there is a theoretical benefit from using antioxidants to help reduce the neurotoxic stress due to reactive oxygen species.

Apr 2, 2024 · Leber hereditary optic neuropathy (LHON) is a genetically inherited disease that causes vision loss. Most people who inherit the condition develop blurred vision that gets …

Over 6,000 people share information about living with LHON, including those affected, carriers, and sighted supporters. Go to the Register page to receive LHON emails. This website should …

LHON is transmitted only through the mother, as it is primarily due to mutations in the mitochondrial (not nuclear) genome, and only the egg contributes mitochondria to the embryo.

Dec 1, 2022 · LHON is a maternally inherited optic neuropathy caused by mutations in mtDNA. For reasons that are not yet clear, the disease exhibits incomplete penetrance and a widely …

Leber hereditary optic neuropathy (LHON) is an inherited form of vision loss. Although this condition usually begins in a person's teens or twenties, rare cases may appear in early …

Leber hereditary optic neuropathy (LHON) is a rare mitochondrial genetic disorder that causes sudden, severe loss of central vision, primarily in young adults. It affects the optic nerves that …

What is LHON? LHON, or Leber's hereditary optic neuropathy, was first defined as a condition in 1871 by the German ophthalmologist, Theodor Leber (pronounced LAY-ber). It is the most …

Jul 25, 2025 · Leber’s Hereditary Optic Neuropathy (LHON) is a rare genetic disorder that leads to significant vision impairment. It primarily affects the optic nerve, which transmits visual …

Leber hereditary optic neuropathy (LHON) is a genetic disease that almost exclusively affects the optic nerves, leading to vision loss (with both eyes eventually affected).