Janus kinase inhibitor - Wikipedia
JAK enzymes are part of the JAK/STAT pathway. This signaling pathway transmits chemical signals from the outside of cells, specifically lymphocytes, and into the cell nucleus.
What are JAK inhibitors and how do they work? - Drugs.com
Jul 15, 2025 · Janus kinase (JAK) inhibitors are a group of medicines that help block immune system signals in the body that can lead to swelling (inflammation) and pain in conditions like …
JAK Inhibitors: Uses, Types, Side Effects, and More
Aug 23, 2025 · In this article, learn about the dosage, uses, and ongoing research underway for JAK inhibitors available in the United States, as well as common side effects, …
JAK Inhibitors 101 - The Rheumatologist
Jul 28, 2025 · The JAK-signal transducer and activator of transcription (STAT) pathway is central to immune dysregulation in many autoimmune diseases due to its role in transducing signals …
Pharmacological targeting of the JAK–STAT pathway: new ...
5 days ago · The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway mediates cellular responses to cytokines and growth factors, and its dysregulation …
JAK inhibitors: an evidence-based choice of the most ...
Recently, Janus kinase inhibitors (JAKi) have been developed to block the effect of proinflammatory cytokines in IMIDs.
Understanding the Mechanism of Action in JAK Inhibitors
Jun 2, 2024 · Jason Hawkes, MD, MS, medical dermatologist in Sacramento, California presented an in-depth overview on the mechanism of action (MOA) of Janus Kinase (JAK) inhibitors, a …
What Is a Janus Kinase Inhibitor and How Does It Work?
Aug 2, 2025 · Janus Kinase inhibitors are employed in the management of various medical conditions, primarily those involving immune system dysregulation and chronic inflammation. …
Definition of JAK inhibitor - NCI Dictionary of Cancer Terms
Some JAK inhibitors are used to treat cancer. They are a type of targeted therapy. Also called Janus kinase inhibitor.
Overview of the Janus kinase inhibitors for rheumatologic and ...
Oct 22, 2025 · The Janus kinases (JAKs) are protein tyrosine kinases (TYKs) that bind to transmembrane type 1 and type 2 cytokine receptors and mediate cellular responses to …