The Supreme Court on Wednesday upheld Tennessee’s ban on gender-affirming care for trans minors in a blockbuster ruling that will bolster efforts by conservative state lawmakers to pass and preserve other divisive laws targeting transgender Americans.

The U.S. Supreme Court upheld a Republican-backed ban in Tennessee on gender-affirming medical care for transgender minors on Wednesday in a setback for transgender rights that could bolster efforts by states to defend other measures targeting transgender people.