San Francisco 49ers tight end George Kittle (No. 85) and fullback Kyle Jusczcyk (No. 44) celebrate a fourth-quarter touchdown ...

Fans and analysts chimed in on Twitter with reactions to the 49ers and Seahawks throwback uniform matchup on Thursday Night ...

Jordan Mason tied a franchise record for rushing as the San Francisco 49ers had its best rushing game since 2019 on Thursday.

SEATTLE — There is debate amongst the 49ers whether Isaac Guerendo intentionally went down before reaching the end zone on ...

After Brock Purdy’s 255-yard, three-touchdown performance against the Seahawks on Thursday, even Fox Sports’ Nick Wright had ...

Shanahan’s defense had its busiest game of the season — 78 snaps versus 65 for the offense. Still, the 49ers won the ...

Brock Purdy connected with George Kittle on two touchdown passes, while Deebo Samuel totaled 117 yards from scrimmage and a ...

Typically, the NFL review process is pretty good about getting calls right. So, when San Francisco 49ers Head Coach Kyle ...

The 49ers (2-3) blew a 10-point, fourth-quarter lead and fell 24-23 to the visiting Arizona Cardinals in record heat at ...

On Thursday night, San Francisco had six players combine for 228 yards and a touchdown rushing, led by Isaac Guerendo's 99 ...

NFL Week 6 odds, picks, predictions, TV, streaming information for Thursday Night Football game between San Francisco 49ers ...

San Francisco 49ers' Deommodore Lenoir (2) returns a blocked field goal for a touchdown during the first half of an NFL ...