Brock Purdy had two costly interceptions against the Cardinals, resulting in a disappointing one-point loss for the 49ers.

Watch San Francisco 49ers quarterback Brock Purdy's best plays vs. the Arizona Cardinals in the Week 5 matchup.

The San Francisco 49ers were thought to be among the favorites to represent the NFC in the Super Bowl for a second straight year, but they haven't ...

The 49ers are 2-3 after losing to the Cardinals at home, and now they have to turn around and play the Seahawks in Seattle on ...

Postgame, both Murray and Brock Purdy had a brief interaction following a hard-fought matchup. The two young quarterbacks, ...

NFL legend Tom Brady recalled facing San Francisco 49ers quarterback Brock Purdy during his first career start in Week 14 of the 2022 season.

Jordan Mason continues to lead the 49ers ground game early in the season. The former undrafted free agent entered Sunday's contest as the NFL's second leading rusher with 447 yards and racked up 14 ...

Watch San Francisco 49ers wide receiver Brandon Aiyuk's Week 5 highlights from his 147-yard game against the Arizona ...

Kyler Murray had a long touchdown run in the first quarter and rallied Arizona with two fourth-quarter scoring drives in the ...

After swapping his cleats for a microphone, the spotlight during Sunday's game between the San Francisco 49ers and Arizona ...

On a scorching hot day at Levi's Stadium in Santa Clara where temperatures approached 100 degrees, the San Francisco 49ers looked like they were well on ...