Diabetes is a lifelong, chronic health condition caused by abnormalities in the body’s production and use of the hormone insulin. Research has shown that the feel-good hormone, dopamine (DA), plays a ...

Obesity increases the body's need for insulin, forcing cells in the pancreas known as beta cells to ramp up insulin ...

Researchers elucidate how BHLHE40, a transcriptional repressor activated in pancreatic β-cells as a response to hypoxia, inhibits the expression of the MAFA protein, thereby leading to impaired ...

Tirzepatide, a drug approved for diabetes and on the fast track for approval as a weight loss therapy, works through a unique ability to activate two different mechanisms the body uses to control ...

How does the body regulate the activity of insulin-producing cells in order to react quickly to changing conditions? Researchers have investigated this question. The hormone insulin plays a central ...

After an initial chemical screening, researchers at the University of Pennsylvania and Weill Cornell Medicine identified the Chk1/Chk2 dual inhibitor AZD-7762 among the strongest to induce insulin ...

Researchers show that obesity alters pancreatic cells to produce cholecystokinin, which drives cancer growth, revealing new links between hormone signaling, cellular stress, and tumor risk.

Researchers describe a key player in the defense mechanism that safeguards against excessive insulin in the body, which can be as harmful as too little. Just over a century has passed since the ...