Trial participants who used eloralintide, a new weight loss medication that, instead of focusing on the hormone GLP-1, targets a different hormone called amylin, lost as much as 20% weight.

A multicenter team including Endeavor Health and Eli Lilly found that once-weekly eloralintide produced dose-dependent weight loss up to 20% over 48 weeks in adults with obesity or overweight without type 2 diabetes.

The race to develop the next generation of weight loss drugs has taken an interesting new turn. In recent research, Eli Lilly’s experimental treatment eloralintide helped people lose a substantial amount of weight—without needing to use the same approach as existing popular medications like Ozempic.

A major new clinical trial involving more than 1,600 people has found that a GLP-1 pill form of the drug orforglipron works about as well as injectable semaglutide for people with type 2 diabetes.

Key Takeaways Current GLP-1 weight-loss meds need to be taken as injections, but new trial results suggest a GLP-1 in pill form could be nearIn an 18-month clinical trial, people with obesity and diabetes lost more than 10% of their starting weight after taking oral orforglipronA researcher in the trial said that the drug could also be a cheaper

GLP-1 medicines, such as tirzepatide (Mounjaro) and semaglutide (Wegovy) work by making people feel fuller for longer

This article was reviewed by Craig Primack, MD, FACP, FAAP, FOMA. Weight loss can be a challenge, even for those who eat healthily and exercise regularly. Injectable weight loss medications — also known as GLP-1 and GIP injections — can help when ...

GLP-1 drugs like tirzepatide and semaglutide offer powerful weight-loss effects but come with unanswered questions about long-term safety, side effects, and global accessibility. Researchers stress the need for independent studies before these treatments can be fully embraced worldwide.

Forbes Health has ranked the best providers for pricing, patient care, effectiveness and ease of use. This way you can cut through the scams and noise to make an informed decision when choosing an affordable GLP-1 weight loss plan.