A new study led by researchers at the University of Pittsburgh (Pitt) and UPMC Hillman Cancer Center has shown that an enzyme called PARP1 is involved in the repair of telomeres, the lengths of DNA ...

Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres. In this ...

In absence of TARG1, ADP-ribose accumulated at telomeres, leading to disruption of telomere replication and premature telomere shortening. To show that these telomere defects were due to modification ...

Imagine your DNA as a set of shoelaces. Telomeres are like the plastic tips at the ends of those shoelaces, preventing them from fraying and unraveling. Structurally, telomeres are repetitive ...

In humans, telomeres are nucleoprotein complexes of tandem 5′TTAGGG3′ DNA repeats and associated proteins at the ends of all 46 chromosomes. Telomere loss beyond a certain threshold causes telomere ...

A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of ...

Transposons are critical drivers of bacterial evolution that have been studied for many decades and have been the subject of Nobel Prize winning research. Now, researchers from Cornell University have ...

A new study reveals that air pollution, traditional herbal medicines and other environmental exposures are linked to genetic mutations that may contribute to the development of lung cancer in people ...

Telomere length and polygenic risk scores (PRS) are linked to idiopathic pulmonary fibrosis (IPF) risk, especially in noncarriers of rare genetic variants. The study identified rare damaging variants ...