Cancer treatment often sounds distant and technical, so stories about it can feel hard to enter. Yet, everyday curiosity ...

Necroptosis and pyroptosis are two forms of programmed cell death with a common feature of plasma membrane rupture. Here we studied the morphology and mechanism of pyroptosis in comparison with ...

Why does pyroptosis take place? Pyroptosis is a form of programmed cell death that occurs during intracellular pathogen infection, as part of the body's antimicrobial response. Cell-surface receptors ...

Pyroptosis is a proinflammatory type of cell death that is associated with gasdermin-mediated membrane hole formation, as well as cell enlargement and lysis. Pyroptosis plays an important role in both ...

Cytokine release syndrome, a side effect of an immunotherapy used to treat leukemia and lymphoma, appears to be caused by the way the intervention kills the tumor cells, according to a mouse study ...

Epstein-Barr virus infection induces the upregulation of glycolysis in intestinal macrophages, which subsequently activates Gasdermin D, NLRP3, interleukin-1β, and interleukin-18 in macrophages within ...

Life is not easy in the cold, lightless reaches of the South China Sea. To survive, microbes have evolved fiercely competitive and extremely resilient. Some build chemical weapons, complex molecules ...

This schematic shows the cell death pathway called pyroptosis, Greek for going down in flames. When activated by a toxin or an infection, the enzyme caspase-1 initiates several reactions inside of the ...