Paroxysmal nocturnal hemoglobinuria (PNH) affects your bone marrow, where your body makes new blood cells. It can be hard to diagnose. For one thing, it's rare. And its symptoms look like those of ...

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder that causes red blood cells to break down. This can lead to symptoms and complications ranging from discoloration of urine to leukemia and ...

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, progressive, multi-system, life-threatening disease, and diagnosing it early in the clinical course is essential for optimizing management ...

Red blood cells carry oxygen to your organs and tissues. These blood cells get created in your bone marrow. That's the soft tissue in the center of your bones. Normally your body breaks down red blood ...

Paroxysmal nocturnal hemoglobinuria leaves red blood cells more vulnerable to destruction. A common side effect is blood clots, known as thrombosis. This is largely preventable with medication to ...

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disease in which the immune system breaks apart the red blood cells (RBCs) in the body. The medical term for this premature rupture of RBCs is ...

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, severe, and potentially life-threatening condition. Treatments targeting the complement pathway have revolutionized its management but have ...

Figure 1: Clonal expansion in paroxysmal nocturnal haemoglobinuria. The term PNH was introduced by J. Enneking in 1928 (Ref. 4). In 1937, Thomas Ham observed that erythrocytes from patients with PNH ...

A retrospective analysis suggested that immune cells play a role in the progression of paroxysmal nocturnal hemoglobinuria (PNH). Furthermore, as Daria Babushok, Division of Hematology-Oncology, ...

Eculizumab, a humanized monoclonal antibody against complement protein C5 that inhibits terminal complement activation, has been shown to prevent complications of paroxysmal nocturnal hemoglobinuria ...

Conference MDAngle offers personal perspectives from conference attendees, showcasing their anticipation, quick takeaways, and insights into how the presented research will affect their patients. The ...