The tumor suppressor protein p53 has a role in cellular apoptosis through the transcriptional regulation of several target genes, including PAC1 (phosphatase of activated cells 1) which inactivates ...

The simplest explanation of cancer is that, for any reason, a cell in our body ignores its biological program and gets loose, multiplying itself again and again, creating a tumour. This has a lot to ...

The gene p53 acts as a tumor suppressor and often is called the ‘guardian of the genome.’ This gene is central to maintaining genomic stability, which prevents mutations from accumulating and leading ...

In the early 1980s, David Gilmour, now an emeritus biochemistry and molecular biology professor at Pennsylvania State University, joined the laboratory of geneticist and biochemist John Lis as a ...

RRS1, a ribosome-biogenesis factor previously linked to tumor growth, is now shown to be indispensable for normal human ...

Researchers have elucidated the role of the p53 gene in ulcerative colitis. The study suggests a potential new drug target to stop disease progression to cancer. Researchers in the lab of Michael ...