A key Alzheimer’s drug has finally revealed its secret. Researchers discovered that lecanemab works by activating the brain’s immune cells—but only through a specific part of the antibody called the ...

As neuronal supporters and immune surveyors, astrocytes and microglia are no mere bystanders to the neuronal mayhem that unfolds in Alzheimer’s disease. At the AD/PD meeting, held March 5-9 in Lisbon, ...

In tauopathies, scientists tend to focus on neuronal tau. They track its pathology and blame it for dysfunctional microglia. Now, researchers led by Celeste Karch at Washington University, St. Louis, ...

Researchers engineer CAR-astrocytes to target and remove amyloid plaques in Alzheimer’s, showing a 50% reduction in brain waste with a single injection.

Northwestern Medicine scientists have discovered how calcium signaling channels in microglia—the primary immune cells of the ...

Northwestern Medicine scientists have discovered that specialized immune cells within the glioblastoma tumor metabolize ...

A growing body of research points to chronic, low-grade inflammation inside the brain as a possible accelerant of Alzheimer’s disease, not just a bystander response to damage already done. The 2024 ...