Myc dysregulation in activated macrophages impairs antioxidant defenses, locking them in a vicious cycle that amplifies type I interferon signaling, driving hyperinflammation and immunosuppression.

In preclinical models, rat insulinoma‑derived beta‑cell line INS‑1 (INS‑1) cells and mouse islets showed rapid, robust Viperin induction after cytokine exposure.

Ultraprocessed foods are strongly linked to increased MS activity, reinforcing the role of proinflammatory diets in disease ...

The 2024 Albert Lasker Award for Basic Medical Research is awarded to Zhijian (James) Chen for his landmark discoveries that explain how DNA stimulates immune responses. DNA is best known as genetic ...

Somatic monoallelic single nucleotide variants in the genes that encode isocitrate dehydrogenase (IDH) 1 and 2 are found in a large subset of diffusely infiltrating gliomas and subsets of acute ...