The endocannabinoid system is the body’s system that regulates an array of other systems in the body. It works to maintain homeostasis by the use of receptors, cannabinoids, and metabolic pathways ...

When compared with other modifiable cardiovascular risk factors, such as hypertension, dyslipidemia and smoking, obesity remains a surprisingly puzzling condition to prevent and treat. The history of ...

Figure 1: Hepatic expression of CB1 receptor during chronic liver diseases. Figure 2: CB1 receptor antagonism decreases accumulation of hepatic myofibroblasts and expression of TGF-β1 in an acute ...

June 9, 2011 (San Antonio, Texas) — Chronic marijuana smokers show a decrease in cannabinoid CB1 receptor activity, which correlates with the number of years of cannabis smoking, but the deficits are ...

NORWOOD, Mass., Dec. 11, 2025 (GLOBE NEWSWIRE) -- Corbus Pharmaceuticals Holdings Inc. (NASDAQ: CRBP), a clinical-stage company focused on oncology and obesity, today announced the completion of the ...

Skye Bioscience’s obesity candidate has failed to reduce weight in a phase 2 study, marking another setback for the CB1 inhibitor class. The biotech had been evaluating a 200-mg weekly subcutaneous ...

The Denver Broncos in Week 8 beat the Dallas Cowboys. It was a dominating victory, beating a tough Cowboys team 44-24, getting the Broncos to 6-2 on the year. Patrick Surtain II and the defense came ...

The endocannabinoid system (ECS) is a complex cell-signaling system that helps regulate your body functions, including sleep and mood, among others. It was identified in the early 1990s by researchers ...

Feel like cannabis isn’t working for you the way it used to? You might be dealing with a high tolerance. Tolerance refers to your body’s process of getting used to cannabis, which can result in weaker ...

Nimacimab is a first-in-class peripherally-restricted negative allosteric modulator antibody inhibitor of CB1 signaling Phase 1 results for SBI-100 Ophthalmic Emulsion, a first-in-class CB1 ...

A recently published article in the journal Scientific Reports has described the remarkable discovery of a previously unknown cannabinoid. Dubbed THCP, the molecule has been shown to be significantly ...