Novo Nordisk’s oral GLP-1 drug didn’t work on Alzheimer’s
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GLP-1 drugs like Wegovy and Zepbound have been racking up sales and new indications, as researchers learn more about how the drugs affect the body beyond just weight loss. But one of the more anticipated studies exploring how they impact Alzheimer’s disease has found no meaningful effect, Novo Nordisk said in a press release on Nov. 24
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Highly Anticipated Alzheimer's Trials Yield Disappointing Results for GLP-1 Drug
The biomarker improvements in the EVOKE studies are worth noting, observed Howard Fillit, MD, of the Alzheimer's Drug Discovery Foundation in New York City, a nonprofit group that supported earlier research of the GLP-1 receptor agonist liraglutide (Victoza, Saxenda) in Alzheimer's disease.
Two large-scale phase 3 trials found that semaglutide did not significantly slow cognitive decline in early-stage Alzheimer’s disease despite improving bio