In the present work, we determine a crystal structure of FPPS in complex with FPP. Intriguingly, the product is bound not to the active site, but to the speculated allosteric pocket of the enzyme.

BMC Pharmacol. 2009;9:1-20. Modeling of such complex kinetics would require a model even more sophisticated than ternary extension of the tandem-two site model. [38] Additionally, differential effects ...

Enzymes are proteins that operate as biological catalysts, which have an important role in the biochemical activities that occur in living organisms. For biochemists, a primary focus of research is ...

In a recent study posted to the bioRxiv* pre-print server, researchers investigated allosteric binders of angiotensin-converting enzyme 2 (ACE2) that significantly inhibit severe acute respiratory ...

Scientists have created a new way of screening compounds that is more sensitive than existing methods, opening up the possibility of finding new drugs for many diseases. Scientists have created a new ...

DOMEK is a multi-step pipeline which leverages mRNA display-derived next-generation sequencing data to derive kinetic information about substrates of post-translational modification enzymes.

The COVID-19 pandemic forced teachers across the globe to embrace remote learning. Although adapting existing materials was relatively easy for lecture-based courses that revolved around theory, ...

Just because an enzyme has an active site doesn’t mean the rest of the enzyme should be disregarded, as though it were so much dead weight. It influences enzyme function, if only by keeping the enzyme ...

Enzymes are biological catalysts that speed up chemical reactions in living organisms. They are essential for life, as they play a crucial role in various biological processes, such as digestion, ...