The tendency of actin to polymerize initially thwarted crystal production. Holmes and colleagues overcame this by complexing rabbit skeletal actin with DNase I, thereby preventing polymerization and ...

Researchers at Kanazawa University report in eLife on deciphering the actin structure-dependent preferential cooperative binding of cofilin. The actin filament is a double-stranded helical structure ...

Researchers have visualized at the molecular level how formins bind to the ends of actin filaments. This allowed them to uncover how formins mediate the addition of new actin molecules to a growing ...

Researchers from Tokyo Medical and Dental University (TMDU), collaborating with scientists from the Marine Biological Laboratory (MBL) and RIKEN, develop a novel technique for live-cell fluorescent ...

This is a preview. Log in through your library . Abstract Arp2/3 complex nucleates branched actin filaments that provide pushing forces to drive cellular processes such as lamellipodial protrusion and ...

The dynamic processes that occur during the growth of actin, via polymerization, and the breakdown of actin both play significant roles in cellular mechanisms like migration and adhesion. Due to the ...

Many actin binding proteins have a modular architecture, and calponin-homology (CH) domains are one such structurally conserved module found in numerous proteins that interact with F-actin. The manner ...

A microscopic flaw in the brain’s cellular scaffolding can shape brain size for life.

Researchers used miniature human brains grown in the lab to uncover why certain genetic mutations lead to abnormally small ...

Immune responses rely on the efficient movement of immune cells within the complex and geometrically unpredictable three-dimensional tissues that make up our bodies. Recent research by the Sixt group ...