Louisville ranked among the top teams in the ACC but suffered at the expense of close-game luck, finishing with an 8-4 record. All four losses -- Notre Dame, SMU, Miami and Stanford -- were by one score. The Cardinals gave Notre Dame their closest game of the season outside of the loss to Northern Illinois .

Led by second-year head coach Jeff Brohm, Louisville finished the 2024 regular season at 8-4, while going 5-3 in ACC play. The Cardinals had 12 players named to the 2024 All-ACC Team, which included wide receiver Ja'Corey Brooks earning a First-Team nod, and running back Isaac Brown being named the Offensive and Overall Rookie of the Year.